A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders
Publication information:
Patrick D. Fischer, Evangelos Papadopoulos, Jon M. Dempersmier, Zi-Fu Wang, Radosław P. Nowak, Katherine A. Donovan, Joann Kalabathula, Christoph Gorgulla, Pierre P.M. Junghanns, Eihab Kabha, Nikolaos Dimitrakakis, Ognyan I. Petrov, Constantine Mitsiades, Christian Ducho, Vladimir Gelev, Eric S. Fischer, Gerhard Wagner, and Haribabu Arthanari. 2021. “A Biphenyl Inhibitor of EIF4E Targeting an Internal Binding Site Enables the Design of Cell-Permeable PROTAC-Degraders”. European Journal of Medicinal Chemistry, 219, Pp. 113435. doi:10.1016/j.ejmech.2021.113435
Abstract
Little research has been published on emotional responses evoked by completely new, innovative food products. The objectives of the present study were 1) to assess the emotional response to new products (fruit and vegetable smoothies in a drink pouch) in two different scenarios: looking at the smoothie pouch, or tasting the smoothie with the smoothie pouch alongside; 2) to compare the information obtained when the participants use photographs or use words to express emotions. In the Pack-alone scenario, similar emotional spaces and sample configurations were obtained with both images and words. In the Pack-and-tasting scenario, the richness of the emotional response increased when using images. In both scenarios, the participants used a greater number of negative emotions when these were presented as images rather than as words. This could be considered an advantage, as it enables some negative emotional loads to be portrayed. The present results also demonstrate that evaluating the emotional response allows effective discrimination between samples with similar overall liking scores.